In "Biblical Perspective" Randall McElwain writes:

As Jewish idioms, love and hatred are relative terms. Love for the things of God is equated with hatred of this life. The term translated lose here is often translated “destroy.” A selfish love for this life destroys the very life one seeks to protect. The great paradox of the gospel is that the only way to gain eternal life is to give up life. The great irony of the gospel is that Jesus, who already possessed eternal life, gave up His life to provide eternal life to humankind.

Discussion: How have you seen a love for this life destroy people's lives?
Source: Jesus, Son of God: Adult Teacher's Insights, page 11.